 |
|
|
| 1 |
130 |
500 |
Pd catalysed coupling |
Air Sensitive |
| 2 |
40 |
360 |
Micheal Addition |
Air Sensitive |
| 3 |
30 |
200 |
Formylation |
Aggressive Reagents |
| 4 |
32 |
380 |
Bromination |
Heterogeneous |
| |
|
|
N-Alkylation (amide) |
Aggressive Reagents |
| 5 |
35 |
200 |
N-Alkylation (amide) |
Heterogeneous |
| 6 |
20 |
160 |
O-Alkylation |
Heterogeneous |
| 7 |
30 |
85 |
Reduction |
Air / Moisture Sensitive |
| |
|
|
Heck |
Air / Moisture Sensitive |
| 8 |
22 |
22 |
C-Alkylation |
|
| 9 |
164 |
920 |
Desilylation |
Aggressive Reagents |
| |
|
|
Lewis Acid Chemistry |
Air / Moisture Sensitive |
| 10 |
20 |
20 |
Grignard |
Air / Moisture Sensitive |
| Table provided courtesy of SmithKline
Beecham Pharmaceuticals |
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